Vacuolar amino acid transporter Avt5p is responsible for lithium uptake in Schizosaccharomyces pombe.
نویسندگان
چکیده
The fission yeast Schizosaccharomyces pombe was sensitive to salinity; cell growth was stopped by 0.5 M NaCl and by 10 mM LiCl. The avt5+ gene encodes a vacuolar transporter with a broad specificity for amino acids. We found that the avt5Delta mutant became highly tolerant of Li+ and Na+ in growth. Concanamycin A-sensitive Li+ uptake as well as cellular Li+ content was lower in the avt5 mutant, suggesting a role of Avt5p in cellular uptake of toxic Li+.
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عنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 74 8 شماره
صفحات -
تاریخ انتشار 2010